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Total active moiety over 1 month (n-15)2

Graph depicting mean plasma concentrations over the course of 29 days.

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This graph depicts the 29-day mean and positive standard deviation of risperidone concentrations (ng/mL) of PERSERIS 90 mg and PERSERIS 120 mg. The first peak occurred on Day 2 and increased until the second peak occurred at 10 to 14 days. Levels then decreased until Day 29.

  • Total active moiety refers to the combined concentrations of risperidone and paliperidone3
  • The pharmacological activity of paliperidone is similar to that of risperidone1

Study description: A Phase I, open-label, single-center, single ascending dose study of the safety, tolerability, and pharmacokinetic profile over 85 days of PERSERIS (90 mg and 120 mg) in 30 patients with clinically stable schizophrenia who were not taking risperidone.2